ANALYSIS OF THE pH-DEPENDENT EQUILIBRIUM RELATIONSHIP BETWEEN THE GUANINE OXIDATION PRODUCTS 5-GUANIDINOHYDANTOIN AND IMINOALLANTOIN
نویسنده
چکیده
Oxidation of 2’-deoxyguanosine (dG) results in the major two-electron product 8oxo-7,8-dihydro-2’-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of dGh is similar to allantoin, an oxidation product of uric acid. Allantoin establishes equilibrium between two constitutional isomers in solution. Therefore, we hypothesize that dGh could establish a similar equilibrium with its constitutional isomer iminoallantoin (dIa).
منابع مشابه
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